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These data do not agree with our findings showing that Caspase-1 cleavage of IL-1 K133R in 293T cells occurs normally, and that it is only impeded when the K133:D129 salt bridge is disrupted (i.e., D129A or K133A mutations)

MICs history dates back to 1935, where its benefits for liver health and metabolism were first noted

These findings mainly support associations and mechanistic inferences, while direct causal validation at the level of cell lineage and fate determination remains lacking

Immunocytochemistry imaging showed a colocalization of HIV-1 p24 with microglia (IBA1+) and astrocytes (GFAP+), but not with neurons (SATB2+) (Fig